Oesophageal squamous cell carcinoma (ESCC): Advances through omics technologies, towards ESCC salivaomics
نویسندگان
چکیده
منابع مشابه
Correction: Elevated Maspin Expression Is Associated with Better Overall Survival in Esophageal Squamous Cell Carcinoma (ESCC)
Tumor suppressor maspin is a differentially regulated gene in the progression of many types of cancer. While the biological function of maspin in blocking tumor invasion and metastasis is consistent with the loss of maspin expression at the late stage of tumor progression, the differential expression and the biological significance of maspin in early stage of tumor progression appear to be comp...
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Esophageal Squamous Cell Carcinoma (ESCC), the major histological form of esophageal cancer, is a heterogeneous tumor displaying a complex variety of genetic and epigenetic changes. Aberrant RNA editing of adenosine-to-inosine (A-to-I) as it is catalyzed by adenosine deaminases (ADARs) represents a common post-transcriptional modification in certain human diseases. In this study, we investigate...
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Esophageal squamous cell carcinoma (ESCC) is the eighth most common cancer worldwide. Epidermal growth factor receptors (EGFR) are often overexpressed in esophageal cancers, thus anti-EGFR inhibitors have been evaluated in ESCC. Afatinib was an irreversible inhibitor of these ErbB family receptors. This study characterized the preclinical activity of afatinib in five ESCC cell lines: HKESC-1, H...
متن کاملClinical significance of serum matrix metalloproteinase-13 levels in patients with esophageal squamous cell carcinoma (ESCC).
OBJECTIVES Matrix metalloproteinase-13 (MMP13) is a highly regulated zinc-dependent endopeptidase and has been reported to be associated with vascular invasion and lymph node metastasis and predicts poor outcome for relatively early stage in esophageal squamous cell carcinoma (ESCC) patients. However, the role of the serum MMP-13 levels in ESCC is still unknown. In the present study, we investi...
متن کاملNicotine Activates YAP1 through nAChRs Mediated Signaling in Esophageal Squamous Cell Cancer (ESCC)
Cigarette smoking is an established risk factor for esophageal cancers. Yes-associated protein 1 (YAP1), the key transcription factor of the mammalian Hippo pathway, has been reported to be an oncogenic factor for many cancers. In this study, we find nicotine administration can induce nuclear translocation and activation of YAP1 in ESCC. Consistently, we observed nuclear translocation and activ...
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ژورنال
عنوان ژورنال: Drug Discoveries & Therapeutics
سال: 2015
ISSN: 1881-7831,1881-784X
DOI: 10.5582/ddt.2015.01042